cycloartanes from euphorbia aellenii rech. f. with their antiproliferative activity

نویسندگان

abdul majid ayatollahi school of pharmacy and phytochemistry research center, shahid beheshti university of medical sciences, tehran, iran.

mustafa ghanadian

suleiman afsharypuor

muhammad iqbal choudhary

چکیده

the cytotoxic chloroform fraction of euphorbia aellenii afforded two cycloartane type triterpenes — cycloart-25-en-3,24-diol (1) and 24-methylene-cycloartan-3-ol (2) — for the first time from this plant. preparation of cycloartane derivatives, 3, 24-o-diacetyl-cycloart-25-en as compound 3 and 3-o-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. the structures of the isolated compounds were elucidated by spectroscopic methods and their activities evaluated by proliferation assay on human peripheral blood lymphocytes (pbls). comparing the results suggested that anti-proliferation effect of these compounds on pbls might be due to the presence of free 3-oh group while masking the free oh groups by acetylation, could induce proliferation activity.

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منابع مشابه

Cycloartanes from Euphorbia aellenii Rech. f. with Their Antiproliferative activity

The cytotoxic chloroform fraction of Euphorbia aellenii afforded two cycloartane type triterpenes — cycloart-25-en-3,24-diol (1) and 24-methylene-cycloartan-3-ol (2) — for the first time from this plant. Preparation of cycloartane derivatives, 3, 24-O-diacetyl-cycloart-25-en as compound 3 and 3-O-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. The ...

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Cycloartanes from Euphorbia aellenii Rech. f. with Their Antiproliferative activity

The cytotoxic chloroform fraction of Euphorbia aellenii afforded two cycloartane type triterpenes — cycloart-25-en-3,24-diol (1) and 24-methylene-cycloartan-3-ol (2) — for the first time from this plant. Preparation of cycloartane derivatives, 3, 24-O-diacetyl-cycloart-25-en as compound 3 and 3-O-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. The ...

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Cycloartanes from Euphorbia aellenii Rech. f. and their Antiproliferative Activity

The cytotoxic chloroform fraction of Euphorbia aellenii afforded two cycloartane type triterpenes-cycloart-25-en-3β,24-diol (1) and 24-methylene-cycloartan-3β-ol (2)-for the first time from this plant. Preparation of cycloartane derivatives, 3β, 24-O-diacetyl-cycloart-25-en as compound 3 and 3β-O-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. The stru...

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عنوان ژورنال:
the iranian journal of pharmaceutical research

جلد ۲۰۱۱، شماره ۳، صفحات ۱۰۵-۱۱۱

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